Project Portfolio

Here are some of the most interesting and exciting drug discovery projects from among more than 130 underway across campus.

Contact us for more information about a project or to learn about other projects in U-M's pipeline. 

Stage Title Primary Disease Area Status
Preclinical Development A kinase inhibitor for the treatment of triple-negative breast cancer
Cancer
Active
Preclinical Development A novel compound for the treatment of lung fibrosis
Lung Disease
Partnered
Lead Optimization A small molecular compound for arthritis and bone erosion treatment
Musculoskeletal Disease
Active
Lead Optimization ALDH inhibitors to treat ovarian cancer
Cancer
Active
Lead Optimization Allosteric modulators of the mu-opioid receptor as analgesics
Pain
Active
Clinical Trials Amlexanox for Type 2 Diabetes / Non-Alcoholic Fatty Liver Disease (NAFLD)
Diabetes, Metabolism & Endocrinology
Active
Clinical Trials ATR-101 for congenital adrenal hyperplasia (CAH)
Cancer
Partnered
Commercialized Cerdelga for Gaucher Disease
Diabetes, Metabolism & Endocrinology
Partnered
Screening Compounds that modulate autophagy
Brain & Neurological Diseases
Active
Commercialized FluMist active immunization
Infectious Disease
Partnered
Lead Optimization Functionally blocking JAML antibodies for the treatment of inflammatory diseases
Allergy & Immune Disorder
Active
Clinical Trials Human double minute 2 (HDM2) antagonist for solid tumors
Cancer
Partnered
Lead Optimization Innovative therapy for chronic kidney disease and other indications
Kidney Disease & Urology
Partnered
Lead Optimization Mcl-1 inhibitors for the treatment of pancreatic and other cancers
Cancer
Active
Lead Optimization Monoclonal antibodies to treat metastasic cancer
Cancer
Partnered
Hit-to-Lead Nef inhibitor to treat HIV
Infectious Disease
Active
Hit-to-Lead Novel Pax2 inhibitors for renal disease
Kidney Disease & Urology
Active
Lead Optimization SHMT2 Inhibitors and Lead Compounds
Cancer
Active
Hit-to-Lead Small molecule activators of human Hsp70
Brain & Neurological Diseases
Active
Preclinical Development Targeted delivery of cancer drugs in personalized medicine
Cancer
Active